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Which drugs can cause depression?

Which drugs can cause depression?

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Beta blocker group:

Beta blockers (atenolol, metoprolol, propranolol, carvediol, satolol) are used to treat high blood pressure, angina, and regulate heart rate. They have the potential to increase depression. Reason: This group of drugs blocks the activity of beta adrenergic, thus inhibiting the activity of norepinephrine, a neurotransmitter. Solution: replace beta adrenergic blockers with other drugs.

Corticosteroid group:

This group includes drugs used as anti-inflammatory, anti-allergic in bone and joint diseases, and used to treat autoimmune diseases such as systemic lupus erythematosus . Reason: corticosteroids reduce the amount of serotonin, a neurotransmitter; thus increasing depression. Manifestations include single or combined symptoms. In adults: mood changes, anxiety, fear, irritability, irritability, excitement or apathy, lethargy, insomnia, lethargy. In children: there are often behavioral disorders such as stuttering and crying. Short-term use tends to cause mania; Long-term use tends to cause depression. 20 – 63% of adults using corticosteroids for a long time have this disorder, of which 6% are severe. Cognitive disorders include deficits in memory, language, speech…


Solution:  can be replaced with non-steroidal anti-inflammatory drugs such as aspirin diclofenac, with anti-allergy drugs, or with other immunosuppressants. In case it is necessary to use corticosteroids, semi-synthetic corticosteroids (prednisolone) should be used at minimum doses. People in a state of effective depression last no more than 10 days.

If long-term use is required (as in some autoimmune diseases), only use the minimum dose that achieves a safe effect and use in intervals as directed by your physician.


Benzodiazepine group:

Groups of drugs commonly used to induce sleep and relax muscles include: diazepam (seduxen), alprazolam (xanax), lorazepam (ativan), temazepam, triazolam. They increase depression. Reason: when they enter the liver they are not completely metabolized; Particularly the elderly, due to poor health, lack metabolic enzymes; As a result, benzodiazepines accumulate and cause toxicity. On the other hand, in the body there is a GABA – Glutamic system in a dynamic balance, in which Glutamic increases excitatory activities, GABA increases inhibitory activities. Benzodiazepines increase the inhibitory activity of GABA, causing depression-like inhibition.


Solution: If depressed people have difficulty sleeping, they should use antidepressants of the tricyclic antidepressants (TCA) group with sedative properties such as amitriptyline. When necessary, TCA antidepressants can be combined with benzodiazepines such as diazepam but at low doses, only for a short time, when first using TCA. Normally, in other cases, only use benzodiazepines in sufficient doses for no more than 10 days.


Group of psychostimulants:

This group often includes methylphenidate (ritalin) modafinil (provigil) used to treat excessive daytime sleepiness, chronic sleepiness, narcolepsy, sleep apnea , and attention deficit hyperactivity disorder (ADHD). They increase depression. Reason: they increase the activity of the dopaminergic system, causing a form of psychotic depression (now also known as schizophrenia ) with negative symptoms (with blunted emotional expression, poor thinking, depression, loss of interest, apathy, loss of motivation…), almost similar to symptoms of depression.


Solution: In case of depression or decreased mental energy due to the decline of neurotransmitters in the synapse below the normal physiological threshold, drugs must be used to restore these substances to the physiological threshold. medications such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs) or monoaminooxydase inhibitors (MAOIs) without using psychostimulants.


Statin group of drugs to treat dyslipidemia :

Cholesterol is a synthetic raw material for substances with a sterol structure, including neurotransmitters. Statins inhibit the synthesis of cholesterol to prevent dyslipidemia and also reduce the synthesis of neurotransmitters. When there is a deficiency of neurotransmitters, it causes depression.


Solution:  To treat dyslipidemia , it is necessary to use an appropriate diet and use other drugs in combination with statins to avoid having to use high doses of single statins. Only use statins within the recommended dose range (for each drug in the group). Cholesterol synthesis occurs in the liver at night, so take it with dinner for greater effectiveness.


What do drug users need to pay attention to?

Normal, healthy people may experience depression when using the above drug groups in high doses and/or for a long time, but when the dose is reduced or the drug is stopped, the depression will gradually disappear and will not cause depression. have a cold.

If people are already at risk of depression, if they use these drugs in high doses and/or for a long time, they will increase the risk, making depression more likely to occur. For example: having an autoimmune disease, chronic bone and joint disease that lasts a long time causes debilitating anxiety, depression, and a built-in risk of depression; If you use high doses of corticosteroids and/or for a long time, depression will easily appear and flare up.

People who already have depression should not use these groups of drugs because they counteract the effects of the depression drugs they are taking, causing depression and making the disease worse.

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